EPOR Protein (C-Term, Extracellular Domain)

N° du produit ABIN1684613

Cette protéine Recombinant EPOR est exprimée dans HEK-293T Cells.

Aperçu rapide pour EPOR Protein (C-Term, Extracellular Domain) (ABIN1684613)

Antigène: EPOR (Erythropoietin Receptor (EPOR))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293T Cells

Pureté: > 97 %, as determined by SDS-PAGE and HPLC

Détail du produit

Attributs du protein: C-Term, Extracellular Domain

Specificité: Optimized DNA sequence encoding extracellular domain of human erythropoietin receptor including a C-terminal Human IgG1 Fc tag was expressed in HEK293 cells.

Attributs du produit: Recombinant EPO receptor is a homodimer protein consisting of two 460 amino acid residue subunit chains, due to glycosylation migrates as an approximately 55 kDa protein on SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Information d'application

Commentaires:

The activity was tested by immobilized recombinant CD131 (10 µg/mL) ability to bind recombinant human EPOR with a range of 0.1-4 µg/mL.

Restrictions: For Research Use only

Stockage

Buffer: PBS solution, pH7.2

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: The lyophilized antibody is stable for at least 1 year from date of receipt at -20 °C. Upon reconstitution, this antibody can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months without detectable loss of activity.

Date de péremption: 12 months

Détail du antigène

Antigène: EPOR (Erythropoietin Receptor (EPOR))

Autre désignation: EPOR

Sujet: IL-7 is secreted constitutively into the conditioned medium of adherent bone marrow stromal cells and thymic cells. Mouse and human keratinocytes have been shown also to express and secrete IL7. Human (152 amino acids, 17.4 kDa) and murine IL7 (129 amino acids) show 60 % sequence homology at the protein level. The human IL7 receptor is an integral strongly glycosylated membrane proteins of 76 kDa expressed on activated T-cells. This receptor has been designated as CD127. IL7 receptors are expressed on pre-B-cells and their progenitors. They are not expressed on mature B-cells. IL7 receptors are expressed also on bone marrow macrophages. Functional IL7 receptors are found on the cell surface of multiphenotypic, biphenotypic, and immature lymphoid progenitors of B-cells with the gene arrangement of the heavy immunoglobulin chain such as those observed in the germ line

UniProt: P19235

Pathways: Signalistation JAK/STAT